Acetazolamide and chronic hypoxia: effects on hemorheology and pulmonary hemodynamics
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چکیده
1 Université Paris 13, Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France 2 UMR Inserm S 665, Université des Antilles et de la Guyane/Université Paris Diderot, Hôpital Ricou, CHU de Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe, France / Laboratoire ACTES EA 3596, Département de Physiologie, Université des Antilles et de la Guyane, 97159 Pointe-à-Pitre, Guadeloupe, France. 3 Cardiovascular Research Center, INSERM U970, Hôpital Européen Georges Pompidou, Université Paris 5, Paris, France 4 Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, URA CNRS 2581, 28 Rue du Dr Roux, 75075 Paris, France, Paris. 5 APHP, Hôpital Avicenne, Service d’Hématologie Biologique; 125, rue de Stalingrad, 93009 BOBIGNY cedex 6 Université de Strasbourg, Faculté de Médecine, EA3072 « Mitochondrie, stress oxydant et protection musculaire », 4 rue Kirschleger, 67085 Strasbourg Cedex, France. Corresponding author: Aurélien Pichon, PhD, Université Paris 13, Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France [email protected] Tel: +33 (0)148387632 Fax: +33 (0)148388924 Word count: 3815 words . Published on April 20, 2012 as doi: 10.1183/09031936.00216011 ERJ Express
منابع مشابه
Acetazolamide and chronic hypoxia: effects on haemorheology and pulmonary haemodynamics.
We tested the effect of acetazolamide on blood mechanical properties and pulmonary vascular resistance (PVR) during chronic hypoxia. Six groups of rats were either treated or not treated with acetazolamide (curative: treated after 10 days of hypoxic exposure; preventive: treated before hypoxic exposure with 40 mg · kg(-1) · day(-1)) and either exposed or not exposed to 3 weeks of hypoxia (at al...
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تاریخ انتشار 2012